One of the stories that has stood out over the last few years in breast cancer treatment was the FDA’s approval in 2015 of the drug palbociclib (Ibrance) for treatment of hormone receptor-positive metastatic breast cancer (MBC). Palbociclib was the first in a category of targeted therapies called CDK 4/6 inhibitors to receive FDA approval. These therapies are used in combination with the hormone therapy fulvestrant and are now part of standard-of-care treatment for patients with hormone-receptor positive MBC. Continue reading
Tag Archives: Targeted Therapies
5 Cancer Research Stories Worth Following – Winter 2018
What’s the latest “need to know” news in cancer research? In this post, I’ll briefly review several of the most interesting cancer research stories that have been in the news this winter.
These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.
Among the topics we cover this time are a new targeted therapy for cancer that’s making its way into breast cancer treatment and the possible negative impact on treatment effectiveness of certain compounds commonly found in food.
5 Cancer Research Stories Worth Following – Fall 2017
What’s the latest “need to know” news in cancer research? In this post, I’ll briefly review several of the most interesting cancer research stories that have been in the news this fall.
These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.
Topics covered this time include approval of a new drug to treat advanced breast cancer and a study on post-traumatic stress disorder in cancer survivors.
A Role for Progesterone in Breast Cancer Treatment?
Back in August 2015, I wrote about an article in the journal Nature on some interesting new discoveries about the role of the hormone progesterone in hormone receptor-positive breast cancer.
The research suggested that adding progesterone to standard treatment with tamoxifen or an aromatase inhibitor could increase the effectiveness of treatment for this subtype of breast cancer, while possibly also lowering toxicity.
Cancer Research UK reports that these findings are now going to be investigated in three clinical trials that are set to begin. Continue reading
5 Cancer Research Stories Worth Following – Fall 2016
What’s exciting in cancer research right now? In this post, I’ll review several of the most interesting cancer research stories that have been in the news this fall.
These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.
Stories worth following this fall include two studies on financial toxicity and new developments in targeted cancer therapies for ovarian cancer and for metastatic breast cancer. Continue reading
Charity Review: Breast Cancer Research Foundation
Many of us are interested in making donations in support of cancer research. But figuring out which organizations will make the most effective use of our contributions isn’t always an easy task. This post is the second in a series in which we’re looking at individual charities that focus primarily on cancer research.
Making a choice based on value for our money means considering factors such as how an organization uses the money it raises, its financial health, and how transparent it is about what has been accomplished with the contributions it has received.
In this post, we review the Breast Cancer Research Foundation, including its mission and approach, history, notable financial facts and results reporting. Continue reading
Cancer Clinical Trials: Why Don’t More of Us Participate?
A recent study got me thinking again about one of the central issues around clinical trials — why don’t more of us participate?
Less than 5 percent of adult cancer patients overall participate in clinical trials, and the rate is even lower for patients from minority populations.
Some of the concerns that keep people from joining clinical trials arise from misperceptions about how clinical trials work. But often patients don’t know to ask about clinical trials and their doctors don’t mention them.
Clinical Trials: How Can Patients Benefit More?
These days the media hype around cancer “breakthroughs” seems to have reached a new high. There have been advances, but there is still such a long way to go before we can say we have real breakthroughs that are changing the outlook for most patients.
There are likely many reasons why progress is so slow. But one thing that would almost certainly make a big difference is if there were true collaboration among researchers conducting clinical trials.
Clinical trials are expensive and time consuming. Patients in clinical trials have chosen to participate not just for their own benefit but also to make a contribution for the greater good. And yet, the knowledge we as a society draw from many clinical trials is often incomplete or even nonexistent.
Review of “The Death of Cancer” by Vincent T. DeVita Jr. and Elizabeth DeVita-Raeburn
The title of this book certainly got my attention and made me curious about what the author had to say. Is the “death” of cancer, or the end of cancer as a deadly disease, really possible? Can we actually win the war on cancer, which has been pronounced a failure by many?
Dr. Vincent T. DeVita Jr. joined the National Cancer Institute as a new doctor during the 1960s. There, he worked directly on some of the most important developments in cancer research coming out of that decade, including the development of a cure for Hodgkin’s lymphoma using combination chemotherapy, a treatment approach that was viewed as exceedingly radical at the time. Continue reading
How Could a Blood Test Be Used Soon in Breast Cancer Care?
We’ve heard a lot in the news over the last year about how researchers are working to develop a blood test to detect cancer, sometimes referred to as a “liquid biopsy”.
What should we make of all this? A blood test, whether for early detection or to aid in treatment and monitoring, would be a wonderful development. But how close are we really?
As I headed to San Antonio for the annual Breast Cancer Symposium in December, I wondered what we might hear there about progress toward a liquid biopsy for breast cancer. I’ve shared some highlights from the Symposium in a recent post. In this post, I’ll share my impressions from the Symposium on where things stand with work toward a liquid biopsy for breast cancer. Continue reading
