One of the stories that has stood out over the last few years in breast cancer treatment was the FDA’s approval in 2015 of the drug palbociclib (Ibrance) for treatment of hormone receptor-positive metastatic breast cancer (MBC). Palbociclib was the first in a category of targeted therapies called CDK 4/6 inhibitors to receive FDA approval. These therapies are used in combination with the hormone therapy fulvestrant and are now part of standard-of-care treatment for patients with hormone-receptor positive MBC. Continue reading
Tag Archives: Metastatic Breast Cancer
Breast Cancer: Are We Still Making Progress?
Learning about progress against cancer has been a main theme here on After Twenty Years since I started this blog about five years ago. One of my first posts in 2013 was a look back at progress against breast cancer in the twenty years since I had been diagnosed.
Now, as we come to the end of 2018, let’s take another look back, but this time let’s focus on what we’ve seen in progress against breast cancer over the last five years or so. Continue reading
Making a Difference: Contributing to Cancer Charities
Every two years, the American Cancer Society publishes a new report on breast cancer trends. The latest report came out earlier this month.
What does the new report tell us? Are we really making a great deal of progress against breast cancer as some of the media stories are presenting it? Or is progress more incremental in nature?
And how might we respond in a way that could make a difference–during this month of October and during the rest of the year as well?
10 Things We Learned About Progress Against Cancer in 2016
2016 was not a year for big breakthroughs in cancer research and improving access to quality care. And yet, it was a year in which many of the issues that need to be addressed if we want to ever see those breakthroughs were front and center.
Those issues include the need for collaborative research and sustained research funding, finding ways to make immune system treatments safer and effective for more patients and addressing the problem of outrageously high drug prices. Continue reading
5 Cancer Research Stories Worth Following – Fall 2016
What’s exciting in cancer research right now? In this post, I’ll review several of the most interesting cancer research stories that have been in the news this fall.
These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.
Stories worth following this fall include two studies on financial toxicity and new developments in targeted cancer therapies for ovarian cancer and for metastatic breast cancer. Continue reading
Charity Review: Dr. Susan Love Research Foundation
One of the best ways to help in the fight against cancer is by making a donation in support of cancer research. But deciding which organizations will make the most effective use of our contributions requires a little homework.
I’ve shared my ideas in earlier posts on contributing to breast cancer charities and focusing on charities that support cancer research specifically. This post is the third in a series in which we’re taking a closer look at individual charities that focus primarily on cancer research.
When it comes to donations, making a choice based on value for our money means considering several factors for any individual charity. These include how the organization uses the money it raises, its financial health, and how transparent it is about what has been accomplished with the contributions it has received. In this post, we’ll review the Dr. Susan Love Research Foundation, including its mission and approach, history, notable financial facts and results reporting. Continue reading
Metastatic Breast Cancer: Learning About Innovative Research Approaches
In a recent post, we looked at highlights of a major report on the status of metastatic breast cancer care and research. That report notes that progress against MBC has slowed and, over the past decade, only about 7% of research publications about breast cancer have been specifically about metastatic breast cancer. It also talked about several things that need to be done to accelerate progress and offered some hope that we are beginning to move in the right direction.
Shortly after writing that post, I attended an event where I learned about some fascinating MBC research that is going on now. The event was the 2016 Advocate Leadership Summit organized by the National Breast Cancer Coalition.
I’ll share here a few of my impressions from parts of the program that focused specifically on MBC research. Videos of these sessions are now available on the NBCC website. Continue reading
Charity Review: Breast Cancer Research Foundation
Many of us are interested in making donations in support of cancer research. But figuring out which organizations will make the most effective use of our contributions isn’t always an easy task. This post is the second in a series in which we’re looking at individual charities that focus primarily on cancer research.
Making a choice based on value for our money means considering factors such as how an organization uses the money it raises, its financial health, and how transparent it is about what has been accomplished with the contributions it has received.
In this post, we review the Breast Cancer Research Foundation, including its mission and approach, history, notable financial facts and results reporting. Continue reading
5 Cancer Research Stories Worth Following – Spring 2016
What’s exciting in cancer research right now? In this post, I’ll review several of the most interesting cancer research stories that have been in the news this spring.
These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.
Stories worth following include a potential new combination treatment for HER2-positive breast cancer, evidence from a large clinical trial of a gene assay that may help reduce unnecessary treatment, and a new study that offers some insights on male breast cancer. Continue reading
Metastatic Breast Cancer: How Can We Accelerate Progress?
For a long time, there has been a critical need for research that is focused specifically on metastatic breast cancer. That means understanding what causes metastasis and how we can intervene to shut down this process even after it has started. Although a true “cure” may not be possible, the question is whether we can treat the disease in such a way that patients live for a very long time with good quality of life.
That should not be so far-fetched an idea. HIV/AIDS not long ago was usually fatal, and now this disease can be managed as a chronic condition with a combination of drugs that patients take for the rest of their lives. Could something like this be possible for breast cancer that has become metastatic?
There have been some amazing advances in the treatment of metastatic melanoma and metastatic lung cancer using immune system therapies. Why have we not seen similar advances in treating metastatic breast cancer?
