A Role for Progesterone in Breast Cancer Treatment?

New research sheds light on the role of progesterone in hormone receptor-positive breast cancer.Back in August 2015, I wrote about an article in the journal Nature on some interesting new discoveries about the role of the hormone progesterone in hormone receptor-positive breast cancer.

The research suggested that adding progesterone to standard treatment with tamoxifen or an aromatase inhibitor could increase the effectiveness of treatment for this subtype of breast cancer, while possibly also lowering toxicity.

Cancer Research UK reports that these findings are now going to be investigated in three clinical trials that are set to begin.  Continue reading

5 Cancer Research Stories Worth Following – Spring 2017

Cancer research stories worth following this spring include a study on the benefits of immunotherapy for breast cancer patients.What’s the latest news in cancer research that we need to know about? In this post, I’ll briefly review several of the most interesting cancer research stories that have been in the news this spring.

These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.

Topics covered this time include studies reported at the recent annual meeting of the American Association for Cancer Research on the use of PARP inhibitors to treat different types of cancer, as well as a study on the benefits of immunotherapy for triple negative breast cancer.

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5 Cancer Research Stories Worth Following – Winter 2017

 

Cancer research stories worth following for Winter 2017 include a possible use of an existing drug in triple negative breast cancer to prevent metastasis.What’s the latest news in cancer research that we need to know about? In this post, I’ll briefly review several of the most interesting cancer research stories that have been in the news this winter.

These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.

Topics covered this time include a possible new use for an existing drug to prevent metastasis in triple negative breast cancer, and new imaging technology that could provide a noninvasive way to monitor ongoing treatment.

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10 Things We Learned About Progress Against Cancer in 2016

A review of cancer research developments in 20162016 was not a year for big breakthroughs in cancer research and improving access to quality care. And yet, it was a year in which many of the issues that need to be addressed if we want to ever see those breakthroughs were front and center.

Those issues include the need for collaborative research and sustained research funding, finding ways to make immune system treatments safer and effective for more patients and addressing the problem of outrageously high drug prices.  Continue reading

5 Cancer Research Stories Worth Following – Fall 2016

Cancer research stories worth following for fall 2016 include a possible new addition to the treatment toolkit for advanced ovarian cancer.What’s exciting in cancer research right now? In this post, I’ll review several of the most interesting cancer research stories that have been in the news this fall.

These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.

Stories worth following this fall include two studies on financial toxicity and new developments in targeted cancer therapies for ovarian cancer and for metastatic breast cancer.  Continue reading

Metastatic Breast Cancer: Learning About Innovative Research Approaches

Researchers are using genomic studies to develop better treatments for metastatic breast cancer.In a recent post, we looked at highlights of a major report on the status of metastatic breast cancer care and research. That report notes that progress against MBC has slowed and, over the past decade, only about 7% of research publications about breast cancer have been specifically about metastatic breast cancer. It also talked about several things that need to be done to accelerate progress and offered some hope that we are beginning to move in the right direction.

Shortly after writing that post, I attended an event where I learned about some fascinating MBC research that is going on now. The event was the 2016 Advocate Leadership Summit organized by the National Breast Cancer Coalition.

I’ll share here a few of my impressions from parts of the program that focused specifically on MBC research. Videos of these sessions are now available on the NBCC website. Continue reading

5 Cancer Research Stories Worth Following – Summer 2016

Cancer research stories worth following this summer include a study on extending the use of aromatase inhibitors in the treatment of hormone receptor-positive breast cancer.What’s exciting in cancer research right now? In this post, I’ll review several of the most interesting cancer research stories that have been in the news this summer.

These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.

Stories worth following include several studies presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in June.  Among those were a study on extending the use of aromatase inhibitors in breast cancer treatment; findings that a web app boosts survival for patients with lung cancer; and, research on the use of a “biosimilar” treatment that can substitute for the breast cancer drug Herceptin. Continue reading

Cancer Clinical Trials: Why Don’t More of Us Participate?

Why don't more cancer patients participate in clinical trials?A recent study got me thinking again about one of the central issues around clinical trials — why don’t more of us participate?

Less than 5 percent of adult cancer patients overall participate in clinical trials, and the rate is even lower for patients from minority populations.

Some of the concerns that keep people from joining clinical trials arise from misperceptions about how clinical trials work. But often patients don’t know to ask about clinical trials and their doctors don’t mention them.

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5 Cancer Research Stories Worth Following – Spring 2016

Cancer research stories worth following this spring include a potential new treatment combination for HER2-positive breast cancer.What’s exciting in cancer research right now? In this post, I’ll review several of the most interesting cancer research stories that have been in the news this spring.

These are a few of the recent stories that seem to have the greatest potential impact, at least from my perspective, and that I know I’ll want to follow as they develop further.

Stories worth following include a potential new combination treatment for HER2-positive breast cancer, evidence from a large clinical trial of a gene assay that may help reduce unnecessary treatment, and a new study that offers some insights on male breast cancer. Continue reading

Metastatic Breast Cancer: How Can We Accelerate Progress?

Genomic studies will play an important role in precision medicine for metastatic breast cancer.For a long time, there has been a critical need for research that is focused specifically on metastatic breast cancer. That means understanding what causes metastasis and how we can intervene to shut down this process even after it has started. Although a true “cure” may not be possible, the question is whether we can treat the disease in such a way that patients live for a very long time with good quality of life.

That should not be so far-fetched an idea. HIV/AIDS not long ago was usually fatal, and now this disease can be managed as a chronic condition with a combination of drugs that patients take for the rest of their lives. Could something like this be possible for breast cancer that has become metastatic?

There have been some amazing advances in the treatment of metastatic melanoma and metastatic lung cancer using immune system therapies. Why have we not seen similar advances in treating metastatic breast cancer?

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